Olivier Sperandio

Vendredi 17 mars 2017, 14h30
Salle Marie Curie du Laboratoire CEISAM à la Faculté des Sciences et Techniques

Chemoinformatics and proteochemometrics contributions to the pharmacological studies of macromolecular interactions : Highlights on Protein-Protein Interations

Olivier Sperandio
Laboratoire de Biologie Structurale des Processus Cellulaires et des Agents Infectieux
Institut Pasteur de Paris
This presentation will focus on the use of in silico approaches that facilitate the pharmacological modulation of macromolecular interactions such as protein-protein interactions (PPI) by small molecules. It combines chemoinformatics and structural bioinformatics techniques to characterize the structural properties of binding cavities present at the core of PPI interfaces and the most suitable physicochemical profile of the small molecules meant to modulate them.