Isabelle Krimm

Jeudi 1er décembre 2016, 14h
Amphithéâtre Denis Escande de l’IRS-UN.

NMR methods and fragment screening for protein ligand identification

Isabelle Krimm
Institut des Sciences Analytiques, UMR 5280
Université Lyon 1
Nuclear Magnetic Resonance is a powerful technique for probing and characterizing protein-ligand interactions. NMR is also particularly robust for fragment screening, generating a low rate of false positives and false negatives. Examples from the literature and from personal research will be discussed to present of overview of NMR-based approches for the identification and the optimisation of protein ligands.
Contact : Agnès Quéméner